DERIVATIVES OF PERHYDROISOINDOLE, METHODS OF THEIR SYNTHESIS, A PHARMACEUTICAL COMPOSITION BASED ON SAID Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of perhydroisoindole of the general formula (I) where R - phenyl; R₁ - phenyl possibly substituted with alkoxy-, hydroxy-, dialkylamino-radicals, or naphthyl, indenyl, thienyl, benzo[a] thienyl or indolyl possibly substituted with halogen, alkoxy-group, alkyl; R₂ - hydrogen, hydroxyl, alkyl, amino- -radicals; R₃ - phenyl possibly substituted at position 2 with C₁-C₂-alkyl, C₁-C₂-alkoxyl; R₄ - fluorine, hydroxyl; R₅ - hydrogen or R₄ and R₅ are hydroxyl, or R₄ together with R₅ forms a bond being alkyl radicals can be direct or branched and have 1-4 carbon atoms, and their stereoisomeric forms also. Synthesized compounds are used as a pharmaceutical composition that acts as an antagonist of substance P. EFFECT: improved method of synthesis. 7 cl, 1 tbl, 40 ex