BENZOXAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITION HAVING PROPERTIES OF ADENOSINE RECEPTOR LIGANDS Russian patent published in 2008 - IPC C07D263/58 C07D413/04 C07D413/12 C07D413/14 A61K31/423 A61K31/4439 A61P25/28 

FIELD: chemistry.

SUBSTANCE: invention refers to benzothiazole derivatives of general formula I and to their pharmaceutically acceptable acid-additive salts as adenosine receptor ligands and based medicinal product. Compounds can be applied for treatment and prevention of diseases mediated by adenosine receptors, e.g., epilepsy, depressions, narcomania, Parkinson's disease. In general formula I R denotes phenyl unsubstituted or substituted with halogen or -SN₂N(CH₃) (CH₂)_nOCH₃, or denotes benzyl, lower alkyl, lower alkoxy-group, - (CH₂)_nOCH₃, or denotes pyridine-3- or -4-yl unsubstituted or substituted with lower alkyl, halogen, morpholinyl, - (CH₂)_n-halogen, - (CH₂)_nOCH₃, - (CH₂)_n-diethylene-imide oxide-4-yl, or (CH₂)_n-tetrahydropyrrole-1-yl; R¹ denotes phenyl unsubstituted or substituted with halogen tetrahydropyran-4-yl, 3,6-2H-2n-pyran-4-yl or morpholine-4-yl; n denotes mutually independent 1 or 2.

EFFECT: production of benzothiazole derivatives which can be applied for treatment and prevention of diseases mediated by adenosine receptors.

9 cl, 4 dwg, 27 ex