METHOD OF PREPARING SOLUBLE COVALENT CONJUGATES Russian patent published in 1999 - IPC

Abstract RU 2127606 C1

FIELD: biochemical methods. SUBSTANCE: soluble covalent conjugates of low-molecular compounds with natural proteins from animal tissue cell chromatin are prepared by precipitating inorganic acid-insoluble proteins from primary solution of cationic protein, followed by redissolving precipitate in medium ionic-strength solution and adding cross-linking agent and low-molecular polar compound to form desired conjugates including proteins inert to proliferative lymphocyte activity. Method is suitable for preparing conjugates which can be used as transporters for substances blocked by hemato-encephalic barrier. EFFECT: improved preparation procedure. 2 tbl

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RU 2 127 606 C1

Authors

Gorjukhina O.A.

Dates

1999-03-20—Published

1994-12-23—Filed