FIELD: medicine. SUBSTANCE: complex has histones H2A, H2B, H3, H4 obtainable from calf thymus tissue forming protein conjugates stable in solutions, heterogeneous in molecular mass. They are built by histones bound with covalent bindings between each other through amine groups of lysine. Method involves joining agent at reaction mixture pH, temperature and incubation time to reach complete modification of available protein amine groups in the preparation. EFFECT: high purity degree; improved pharmaceutical properties. 2 dwg
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