IMMUNOMODULATING PREPARATION "NEOFERON" SHOWING ANTIVIRAL ACTIVITY Russian patent published in 1999 - IPC

Abstract RU 2129878 C1

FIELD: biotechnology, pharmacy, veterinary science. SUBSTANCE: invention relates to preparing ready medicinal forms showing immunomodulating and antiviral properties as a lyophilized form for parenteral administration and in tablets for per os ingestion. Preparation has a complex consisting of the following recombinant cytokines: 1) hybrid protein T-FNO-T isolated from microorganism where recombinant plasmid pThy-325 encoding protein synthesis is introduced; 2) interferon alpha-2 isolated from the strain E. coli containing plasmid pTTαKm-1,4 encoding protein; 3) interferon-gamma isolated from the strain Escherichia coli MC-106 containing plasmid (pTTγKm2)T3γ encoding protein. For parenteral administration (form 1) the preparation is prepared at the following ratio of components in volume 1cm3: hybrid protein T-FNO-T 0.0000001%; interferon alpha-2 0.0000001-0.0000002%; interferon-gamma 0.0000001-0.0000002%; polyglucin 1.5-2.0%; saline buffer system, pH 7.0-7.2, 1.03-1.06%, apyrogenic water - the rest. Buffered physiological sodium chloride solution is used as a saline buffer system. For oral administration (form 2) the preparation is prepared at the following ratio of components, per 1 tablet, wt.-%: hybrid protein T-FNO-T 0.00000005%; interferon alpha-2 0.00000005%; interferon-gamma 0.0000001-0.0000002%; aluminium hydroxide 4-5%; starch 3-4%; calcium (magnesium) stearate 0.2-0.25%, glucose hydrate - the rest. Preparation shows immunomodulating activity and can be used for the complex nonspecific prophylaxis in treatment of patients with infectious sicknesses. EFFECT: enhanced immunomodulating and an antiviral activity. 4 ex

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RU 2 129 878 C1

Authors

Zinchenko E.V.

Zinchenko V.B.

Shmelev V.A.

Cherepanov P.A.

Panin A.N.

Gruzdev K.N.

Dates

1999-05-10Published

1996-04-24Filed