PREPARATION SHOWING IMMUNOMODULATING ACTIVITY Russian patent published in 1998 - IPC

FIELD: biotechnology, veterinary science. SUBSTANCE: invention proposes medicinal form of highly purified immunologically active preparation based on hybrid protein T-TNF-T. Hybrid protein T-TNF-T is isolated from microorganism where recombinant plasmid pThy325 encoding protein biosynthesis is inserted. Preparation has the following components, wt.-%: hybrid protein 0.0008-0.0015; stabilizing additions 10-20, saline buffer system at pH = 7.0-7.2 1.03-1.06, and water - the rest. Polyglucine, gelatinol, sucrose were used as stabilizing additions and buffered sodium chloride physiological solution - as saline buffer system. Preparation can be used for nonspecific prophylaxis and treatment of infectious diseases. EFFECT: enhanced effectiveness of preparation. 3 cl, 6 tbl