FIELD: medicine, clinical immunology. SUBSTANCE: invention relates to development of the mixed vaccine containing hepatitis B virus antigen (HBsAg) obtained by culturing the transformed cells S. cerevisiae, strain VKPM Y-2203, purified concentrated diphtheria anatoxin and purified concentrated tetanus anatoxin and merthiolate, aluminium hydroxide gel and a pharmaceutically acceptable solvent also. EFFECT: decreased dose of hepatitis B antigen, enhanced immunological activity of tetanus, diphtheria and hepatitis components in the mixed vaccine preparation as compared with that of the separate preparations. 3 tbl
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