DISUBSTITUTED FURANONES, THIAZOLES AND PENTENONES AS INHIBITORS OF CYCLOOXYGENASE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF PATIENT TREATMENT Russian patent published in 1999 - IPC

FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention describes a compound of the formula (I) or its pharmaceutically acceptable salt where: X-Y-Z is taken from the group involving: (a) -C(O)-CH₂CH₂-; (b) -C(O)-O-CR⁵(R^5′); (c) -S-N=CH-; (d) -CH=N-S- when (b) means a double bond and (a) and (c) mean simple bonds; and X-Y-Z means the group = N-S-CH= when (a) and (c) mean double bonds and (b) means a simple bond; and R¹ is taken from the group involving: (a) S(O)₂CH₃; (b) S(O)₂NH₂; (c) S(O)₂NHC(O)CF₃; R² is taken from the group involving: (a) C₃,C₄,C₅,C₆,C₇-cycloalkyl; (b) mono-, di- or trisubstituted phenyl where substitutes are taken from the group involving: (1) hydrogen atom; (2) halogen atom; (3) C_1-6-alkoxy-group; (4) C_1-6-alkylthio-group; (5) CO₂H; R⁵ and R⁶ each independently is taken from the group involving: (a) hydrogen atom; (b) C_1-6-alkyl. Invention describes also a method of synthesis the above indicated compounds, a method of patients treatment and a pharmaceutical composition based on compounds of the formula (I) which is used for treatment of patients with an cyclooxygenase-mediated inflammatory disease. EFFECT: improved method of synthesis, anti-inflammatory effect. 24 cl, 4 tbl, 56 ex