FIELD: medicine. SUBSTANCE: described is method of preparing compounds of formula I: wherein Ra and RB are hydrogen or halogen by reacting compound of formula
wherein X2 is chlorine or bromine with compound of formula
in solvent in the presence of base and transition metal-based catalyst to give compound of compound of formula
which is oxidized to compound of formula I. Compounds of formula I are potent cyclooxihenase-2-inhibitors and are useful in medicine. EFFECT: more efficient preparation method. 15 cl, 2 ex
Authors
Dates
2000-12-10—Published
1995-09-12—Filed