METHOD OF PREPARING PHENYL HETEROCYCLES, AND INTERMEDIATE COMPOUND Russian patent published in 2000 - IPC

Abstract RU 2160257 C2

FIELD: medicine. SUBSTANCE: described is method of preparing compounds of formula I: wherein R_a and R_B are hydrogen or halogen by reacting compound of formula wherein X₂ is chlorine or bromine with compound of formula in solvent in the presence of base and transition metal-based catalyst to give compound of compound of formula which is oxidized to compound of formula I. Compounds of formula I are potent cyclooxihenase-2-inhibitors and are useful in medicine. EFFECT: more efficient preparation method. 15 cl, 2 ex

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RU 2 160 257 C2

Authors

Richard Dezmond

Ul'F Dolling

Ben Mehrk'Jun

Richard Tillajer

Dehvid Chehn

Dates

2000-12-10—Published

1995-09-12—Filed