CYSTEIC CATHEPSIN PROTEASE INHIBITOR Russian patent published in 2010 - IPC C07C255/46 A61K31/275 A61P19/00 

FIELD: chemistry.

SUBSTANCE: novel compounds of formula or their pharmaceutically acceptable salts or stereoisomers have cathepsin K, L, S and B inhibitory properties. In the formula R¹ and R², taken together with the carbon atom with which they are bonded, form a C_3-4cycloalkyl; R³ is C_1-6alkyl which is substituted with one-four fluorine or chlorine atoms; R⁴ is a C_1-6alkyl which is substituted with one-five halogen atoms; R⁵ is hydrogen; each D independently denotes phenyl; R⁶ is hydrogen or C_1-6alkyl, which can be substituted with one-two hydroxyl groups or two-six halogen atoms; R⁷ is C_1-6alkyl which can be substituted with two-five halogen atoms; n equals two. The invention also relates to a pharmaceutical composition and to use of said compounds to prepare a medicinal agent.

EFFECT: more effective use of the compounds.

8 cl, 12 ex