METHOD OF PREPARING 1,4: 3,6-DIANHYDRO-D-SORBITOL Russian patent published in 1999 - IPC

Abstract RU 2131434 C1

FIELD: medicine. SUBSTANCE: 1,4: 3,6-dianhydro-D- sorbitol (sorbide or isosorbide) is semiproduct in the manufacture of medicinals based on mono- and dinitroderivatives thereof which are useful as vasodilating agent of prolonged activity in treating hypertension, stenocardia and other cardiovascular diseases. Method comprises boiling food sorbitol at 130- 50 C in xylol with water separator till water separation ceases completely in the presence of n-toluene-sulfonic acid catalyst in amount of 5.0% based on sorbitol weight. EFFECT: simplified method and increased yield of the desired high-quality product. 2 tbl

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RU 2 131 434 C1

Authors

Khusainov A.R.

Zjuzin Ju.V.

Dodukh V.G.

Kochergin P.M.

Dates

1999-06-10—Published

1990-04-09—Filed