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2 131 878

(13)

(51)

IPC

(21) (22)

Application

94042916/04, 1994-12-06

(22)

Actual filing date

1994-12-06

(45)

Published

1999-06-20

(72)

Inventor

Nedel'Ko KujundzhichGabriela KobrekhelZhel'Ko Kelnerich

(73)

Holder

Pliva Farmatsojtska, Kemijska, Prekhrambena I Kozmetichka Industrija, Dionichko Drushtvo

9A-N-(N'-CARBAMOYL)- OR 9A-N-(N'-THIOCARBANOYL)-DERIVATIVES OF 9-DEOXO-9A-AZA-9A-HOMOERYTHROMYCIN A, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON SAID Russian patent published in 1999 - IPC

Abstract RU 2131878 C1

FIELD: organic chemistry, antibiotics, pharmacy. SUBSTANCE: invention relates to 9a-N-(N'-carbamoyl)- or 9a-N-(N'-thiocarbamoyl)-derivatives of 9-deoxo-9a-aza-9a-homoerythromycin A of the formula (I) where R means C_1-3-alkyl, C_6-10-aryl or C_6-10-aryl-C_1-3-alkyl, 5- or 6-membered aromatic ring containing 1 or 2 heteroatoms taken from nitrogen or oxygen atom; X is O or S. These compounds are new semisynthetic macrolide antibiotics of azalide order showing antibacterial effect. EFFECT: new macrolide azalide antibiotics. 17 cl, 1 tbl, 9 ex

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RU 2 131 878 C1

Authors

Nedel'Ko Kujundzhich

Gabriela Kobrekhel

Zhel'Ko Kelnerich

Dates

1999-06-20—Published

1994-12-06—Filed