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2 135 490

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C1

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IPC

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Application

97111207/04, 1997-07-01

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Start date

1997-07-01

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Actual filing date

1997-07-01

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Published

1999-08-27

(72)

Inventor

Mladen TrkovnikZrinka IvezichLerka Polak

(73)

Holder

Pliva Farmatsojtska, Kemijska, Prekhrambena I Kozmetichka Industrija, Dionichko Drushtvo

COUMARIN DERIVATIVES AND METHOD OF PREPARING THEREOF Russian patent published in 1999 - IPC

Abstract RU 2135490 C1

FIELD: medicine. SUBSTANCE: new coumarin derivatives of formula I: wherein R1 is NH2 or -NHCH=(CO2C2H5)2; R2=R3=R4 is H; R5 is F; R1=R3 is -NHCH=C(CO2C2H5)2; R2=R5=R4 is H; R1 is H, OH; R2=R3=R4 is H; R5 is -NHCH=C(CO2C2H5)2; R1=R3=R5 is H; R2 is CH3 or CF3; R4 is -NHCH=C(CO2C2H5)2. Said compounds are useful for synthesis of new coumarin derivatives having potential biological activity, namely antimicrobial and antitumor activity. EFFECT: improved properties of the title compounds. 12 cl, 16 ex

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RU 2 135 490 C1

Authors

Mladen Trkovnik

Zrinka Ivezich

Lerka Polak

Dates

1999-08-27—Published

1997-07-01—Filed

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