COUMARINQUINOLONE CARBOXYLIC ACIDS AND METHOD OF THEIR SYNTHESIS Russian patent published in 2001 - IPC

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to novel coumarinquinolone carboxylic acids where pyridone system of condensed at positions 3,4-, 6,7- and 7,8- of coumarin system of the general formula (I) where R¹,R² is -NHCH=C(CO₂R⁶)CO; R³ is NO₂ or NH₂; R⁴ = R⁵ is H ; R⁶ = H or C₂H₅; R¹,R² is -NHCH=C(CO₂R⁶)CO; R³ = R⁴ is H; R⁵ is F; R⁶ is H or C₂H₅; R¹,R² is CO(CO₂R⁶)C=CHNH; R³ = R⁴ = R⁵ is H; R⁶ is H or C₂H₅; R¹,R² = R³,R⁴ is -NHCH=C(CO₂R⁶)CO; R⁵ is H ; R⁶ = H or C₂H₅; R¹ is H or OH; R² = R⁵ is H; R³,R⁴ is -NHCH=C(CO₂R⁶)CO; R⁶ is H or C₂H₅; R¹ is OH; R² = R³ is H; R⁴,R⁵ is -CO(CO₂R⁶)C=CHNH; R⁶ is H or C₂H₅; R¹ = R⁵ is H; R² is CH₃ or CF₃; R³,R⁴ is CO(CO₂R⁶)C=CHNH; R⁶ is H or C₂H₅ and their pharmaceutically acceptable salts also. New compounds are inhibitors of tested bacterium strains, they inhibit proliferation of mammary gland cancer, pancreas cancer and larynx cancer cells. Invention describes also methods of synthesis of new compounds. EFFECT: new compounds indicated above, improved method of synthesis, valuable antitumor properties. 21 cl, 10 tbl, 18 ex