FIELD: medicine. SUBSTANCE: composition is produced as globules with controlled release of drugs having nucleus with regular seed or seed with homogeneously distributed glycocorticosteroid described in the invention application. Regular seed nucleus has budesonide or its 22R-isomer layer. The drugs show significant advantages when compared to other glycocorticosteroids of systemic activity and other drugs earlier applied for treating Kron disease. EFFECT: no systemic adverse side effects; high speed in passing metabolism pathway; high reliability when applied as supporting therapy in acute phase of disease. 25 cl, 8 tbl
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