FIELD: organic chemistry. SUBSTANCE: product: (22R,S)-16a, 17a-butylidenedihydroxy-11b, 21-dihydroxypre- gna-1,4-diene-3,20-dione. Rotation angle at 25 C is (+)100 (c 0.2 in dichloromethane), molecular mass is 430. Reagent 1: 11b,16a,17a,21-tetrahydropregna-1,4-diene-3,20-dione. Reagent 2: butanal. Process conditions: in acetonitrile medium, in the presence of p-toluenesulfoacid. Reaction is stopped by water addition and aqueous sodium hydrocarbonate. Recrystallization is carried out from methylene chloride and methanol by addition of ligroin, hexane, cyclohexane or heptane, and recrystallization is carried out in methanol and water. Synthesized compounds were used in medicine for synthesis of known antiinflammatory and antiallergic drug. EFFECT: improved method of synthesis. 3 cl
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