FIELD: biotechnology, microbiology. SUBSTANCE: invention relates to a new method (two variants of bacterial bioconversion) for synthesis of trans-hydroxysulfone that is a precursor of inhibitors of carbonate dehydrogenase and exhibiting the local effect. Method of bioconversion is carried out in an aqueous carbohydrate medium in the presence of microorganism Rhodotorula rubra ATCC 74283 or Rhodotorula piliminae 32762 and a substrate compound. Culturing process is carried out under aerobic conditions at 20-50 C and pH 4.5-8.0 followed by isolation of the end product. Method provides diastereomeric excess (above 95%) of the end product. Method can be used for production of drugs for treatment of patients with ocular hypertension. EFFECT: simplified method, decreased cost of production. 6 cl, 3 ex
| Title |
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Number |
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