HETEROCYCLIC COMPOUND OR ITS TAUTOMERIC FORM AND/OR PHARMACEUTICALLY ACCEPTABLE SALT AND/OR PHARMACEUTICALLY ACCEPTABLE SOLVATE, PHARMACEUTICAL COMPOSITION DECREASING BLOOD GLUCOSE LEVEL, METHOD OF TREATMENT AND/OR PROPHYLAXIS OF HYPOGLYCEMIC PATIENTS Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes a new heterocyclic compound of the formula (I): A¹-X-(CH₂)_n-O-A²-A³-YR² or its tautomeric form and/or pharmaceutically acceptable salt and/or pharmaceutically acceptable solvate where A¹ means benzoxazolyl or pyridyl; A² means benzene ring optionally substituted with C_1-6-alkyl or C_1-6-alkoxy-group; A³ means a fragment of the formula -(CH₂)_m-CH(OR′)- or -(CH₂)_m-1-CH=C(OR′)- where R¹ means C_1-6-alkyl optionally substituted with up to three substituents taken from the group including halogen atom, C_1-6-alkoxy- and carboxyl-group; or R¹ means naphthyl or phenyl optionally substituted with up to three substituents taken from the group including halogen atom, C_1-6-alkyl and C_1-6-alkoxy-group or R′ means phenyl-C_1-6-alkyl and m = 1-5; R² means amino-group or OR³ where R³ means hydrogen atom or C_1-6-alkyl or when Y means a bond; R² means triazolyl, tetrazolyl or oxadiazolyl; X means NR where R means C_1-6-alkyl; Y means CO or CS or a bond at condition that Y means a bond only if R² means triazolyl, tetrazolyl or oxadiazolyl; and n = 2-6. New compounds show good activity with respect to blood glucose decrease and therefore they can be used for treatment and/or prophylaxis of hyperglycaemia and especially for treatment of patients with diabetes mellitus of type-2 and also for treatment and prophylaxis of cardiovascular diseases, in part, atherosclerosis. Invention describes pharmaceutical compositions based on compounds of the formula (I) that can be used in medicine. EFFECT: enhanced antidiabetic effectiveness of compound synthesized. 15 cl, 1 tbl, 78 ex