DIMER OF MOLECULAR VARIANT OF APO-LIPOPROTEIN, METHOD OF ITS PREPARING AND PHARMACEUTICAL COMPOSITION ON SAID Russian patent published in 1999 - IPC

FIELD: medicine, pharmacy. SUBSTANCE: invention relates to preparing dimer of molecular variant of apo-lipoprotein AI-Milano that can be used for making drugs used for prophylaxis and treatment of patients with atherosclerosis and cardiovascular diseases. The claimed dimer exhibits purity, at least 90%, but preferably at least 98%. Dimer of apo-lipoprotein AI-Milano is prepared from donor blood or by recombinant technology in an expression system in E. coli or as an intracellular fused protein in E. coli. Pharmaceutical composition containing dimer of apo-lipoprotein as an active component can has additionally a carrier and/or stabilizing agent, preferably of lipid nature, and/or an agent decreasing lipid content in the body. Dimer-containing pharmaceutical composition can be used for treatment of patients with atherosclerosis and cardiovascular diseases as prodrug for apo-lipoprotein monomer for thrombosis prophylaxis. Method ensures to obtain dimer of apo-lipoprotein as a pure form showing the prolonged half-time period in plasma and improved capability to promote fibrin splitting in the body as compared with that of monomer. EFFECT: improved properties and effectiveness of dimer. 27 cl, 13 dwg, 9 tbl, 10 ex