METHOD FOR PREPARING SULFUR-CONTAINING IMIDAZOLE DERIVATIVES AND INTERMEDIATE PRODUCTS Russian patent published in 1999 - IPC

FIELD: organic synthesis. SUBSTANCE: new method for preparing sulfur-containing imidazole derivatives expressed by general formula I: R₄-C₆H₄-C₆H₄-CH₂-NC₄R_tR₂R₃ consists in that compound of formula A: is brought into reaction with an oxidant to obtain compound of formula B: that further reacts with compound II: , wherein optional functional groups can be protected, to give compound C: , which is brought into reaction with compound III: to give compound D: . The latter undergoes addition reaction on radical C by means of a reagent capable of introducing substitute R12

, wherein optional functional groups can be protected, to give compound E: . When necessary, compound E undergoes O->S substitution to give compound L: . Compounds E and L are subjected to cyclization reaction resulting in formation of compound I. All radical are defined in claim 1 of invention. Compounds of general formula I exhibit antagonistic properties for angiotensin II receptor and inhibits angiotensin II activity. EFFECT: new compounds controlling angiotensin II activity prepared. 7 cl, 6 ex