SULFUR-CONTAINING IMIDAZOLE DERIVATIVES, METHOD OF THEIR SYNTHESIS, NEW INTERMEDIATE COMPOUNDS AND PHARMACEUTICAL COMPOSITION Russian patent published in 1997 - IPC

FIELD: organic chemistry. SUBSTANCE: product: sulfur-containing derivatives of imidazoles of the formula (I) where: R₁ means alkyl; R₂ means hydrogen, hydroxymethyl, carboxy-group and so on; R₃ means carboxy-group, hydroxymethyl, thio(lower)alkyl, carboxy(lower) alkyl, hydrogen, formyl and so on; m = 1; Y means phenyl substituted with methoxy- or carboxy-group or free biphenyl or biphenyl substituted with cyano-group, carboxy-group, lower alkylcarbonyl-group or tetrazoline. Reagent 1: compound of the formula (II) . Reagent 2: compound of the formula (III) (CH₂)_m-Y¹ where Z means halogen atom or sulfonate. Product of the formula (II). Pharmaceutical composition showing hypotensive active and containing compounds of the formula (I) as an active component taken at effective amount and pharmaceutical additions. Synthesized compounds were used in medicine as pharmaceutical agents. EFFECT: improved method of synthesis. 5 cl