TETRASUBSTITUTED DERIVATIVES OF IMIDAZOLE, METHODS OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS AND PHARMACEUTICAL COMPOSITION Russian patent published in 2001 - IPC

Abstract RU 2174513 C2

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel tetrasubstituted derivatives of imidazole of the formula (I) where R1 is alkyl or alkylthio-group; R2 is C1-C8-alkylthio-group possibly substituted with one or some halogen atoms or radical -CO-Z where Z is a free carboxyl radical or that converted to salt or ester; R3 is radical where X means oxygen atom or radical of the formula (a) (radicals D1,D2 and R5 have values given in p. 1 of the invention claim) and also their acid addition salts. Synthesized compounds show antagonistic properties to receptors of angiotensin-II, in part, they inhibit vasoconstrictive effect and trophic effect at the level of myocytes. Invention describes 3 methods of synthesis of compounds of the formula (I), pharmaceutical composition and intermediate compounds. EFFECT: new compounds indicated above, improved method of synthesis, valuable pharmacological properties. 11 cl, 66 ex

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RU 2 174 513 C2

Authors

Alan Korb'E

P'Er Depre

Mishel' Fortehn

Zhak Gijom

Bertran Ehkman

Dates

2001-10-10Published

1995-02-27Filed