1,5-BENZODIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING ON SAID Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes the novel derivatives of 1,5-benzodiazepine of the general formula (I) and their pharmaceutically acceptable salts where R¹ - phenyl or C_1-6-alkyl group being indicated alkyl group can be substituted with C_3-7-cycloalkyl or C_7-11-cycloalkyl (bridge) group; R² means phenyl group possibly substituted with substituents taken from the following ones: halogen atom, C_1-4-alkyl, trifluoromethyl or (CH₂)_nR⁴ where R⁴ means hydroxy- or C_1-4-alkoxy-group and n = 0; R³ means a group AlkN-R⁸R⁹ where ALk is a direct C_2-6-alkylene chain possibly substituted with hydroxyl group; R⁸ and R⁹ in common with nitrogen atom to which they bound form 5-7-membered saturated heterocyclic ring possibly containing an additional heteroatom taken from the following ones: oxygen or nitrogen atom; R¹⁰ means halogen atom; X means NH residue; m = 0 or 1. The above indicated compounds are antagonists of gastrin and cholecystokinin. EFFECT: new compounds indicated above, valuable pharmacological properties. 12 cl, 18 ex