DERIVATIVES OF 1,5-BENZODIAZEPINE, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION CONTAINING ON SAID Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of 1,5-benzodiazepine of the formula (I) where X is H; R¹ - radical of the formula (II) or NR⁴R⁵; R² - indole, benzofuran, thiophene, benzothiophene, indoline, quinoline or 4-oxobenzopyrane; phenyl possibly substituted with halogen atom, carboxy-, amino- or dimethylamino-group or NHR¹¹; R¹¹ is 7-indazolyl; R³ - H, C_1-6-alkyl, C_3-6-cycloalkyl or phenyl and also their physiologically acceptable salts and solvates that show agonistic activity with respect to cholecystokinin-A receptors that ensures to use the indicated compounds for control of function of hormones gastrin and cholecystokinin in mammals. EFFECT: improved method of synthesis, agonistic activity of compounds to receptors. 10 cl, 9 tbl, 18 ex