CYTOKINES PRODUCTION-INDUCING CARBAMATES AND UREAS Russian patent published in 1999 - IPC

FIELD: pharmaceutical chemistry. SUBSTANCE: new carbamates and ureas are provided with general formula I (in description), wherein R₁ is optionally substituted C₁-C₂₀-alkyl, optionally substituted cycloalkyl, optionally substituted phenyl-lower alkyl group; R_a and R₃, the same or different, (C₁-C₆)-alkyl; R₂, R_b, and R_c, the same or different, carboxyl or protected carboxyl group; X oxygen or nitrogen; and R₄ hydrogen atom or amine-protection group; above-mentioned substituents being halogens, hydroxyl, lower alkyl, lower alkoxyl, amino, mono- or di-lower alkylamino groups, carboxyl, formyl, lower-alkoxycarbonyl; or their pharmaceutically acceptable salts. New carbamates and ureas present first examples of non- peptide analogs of bacterial components of cell shell and do not contain constituent common for precedent level. Described are also method for preparing compounds I and pharmaceutical composition inducing endogenous production of growth factors JL-6 and C₃F²⁵ controlling production of neutrophils in mammalian marrow. EFFECT: extended drug choice. 6 cl, 9 tbl, 90 ex