HETEROCYCLIC IMIDAZOLE COMPOUNDS, METHOD FOR THE PRODUCTION AND USE THEREOF Russian patent published in 2019 - IPC C07D471/04 C07D477/02 C07D487/04 A61K31/437 A61K31/52 A61P35/00

Abstract RU 2686314 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a heterocyclic imidazole compound of general formula (I), in which R is hydrogen, halogen, C₁-C₆alkoxy or C₁-C₆halogenalkyl; one of X, Y and Z is nitrogen, and others are CH or one of X, Y and Z is CH, and others are nitrogen; M is nitrogen or CR₁; R₁ is hydrogen, oxygen, C₁-C₆alkyl or C₁-C₆halogenalkyl. Invention also relates to a method for producing a compound of general formula (I), to use of the compound.

EFFECT: new heterocyclic imidazole compounds of general formula (I) are produced, having inhibiting properties of poly(ADP-ribose)-polymerase (PARP).

14 cl, 5 tbl, 24 ex

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RU 2 686 314 C1

Authors

Fan, Xing

Qin, Jihong

Dates

2019-04-25—Published

2016-04-15—Filed