DERIVATIVES OF HYDROXAMIC OR CARBOXYLIC ACID AND PHARMACEUTICAL OR VETERINARY COMPOSITION ON SAID Russian patent published in 1999 - IPC

FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to derivatives of hydroxamic or carboxylic acid of the general formula (I) where X is COOH or CONHOH; R - H, methoxy, alkyl, C_2-6-alkenyl, phenylalkyl or the group BSO_nA-; n = 0 or 1; B is 5- or 6-membered heterocyclic ring containing sulfur or nitrogen as a heteroatom; A means -CH₂-; R₂ - alkyl, phenylalkyl; R₃ - tert.-butyl, 1-benzylthio-1-methyleth-1-yl or the specific by-side chain of alanine, valine, leucine or phenylalanine; R₄ - phenyl or 5- or 6-membered heterocyclic ring containing sulfur or nitrogen as a heteroatom that can be condensed with benzene ring or 5-, 6- or 7-membered heterocyclic ring; R₅ - H or alkyl; or their salt or solvate that are inhibitors of metalloproteinases causing tissue degeneration and inhibitors of tumor necrosis factor release from cells. EFFECT: valuable biochemical properties of compounds. 6 cl, 1 tbl, 39 ex