DERIVATIVES OF HYDROXAMIC ACID, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL OR VETERINARY COMPOSITION BASED ON SAID Russian patent published in 1999 - IPC

FIELD: organic chemistry. SUBSTANCE: invention proposes derivatives of hydroxamic acid of the formula (I): HO-NH-CO-CH(OH)-CHR₂-C(O)-NH-CHR₃C(O)N-R₄R₅ where R₂ is C₁-C₆-alkyl; R₃ is C₁-C₆-alkyl or R₇ is -B-; n = 0, 1; B is divalent C₁-C₆-alkyl; R₇ is CO-NH-OH, cycloalkyl, 5-6-membered heterocycle containing N or S as heteroatom, phenyl, phenyl-substituted phenyl; R₄ is H, CH₃; R₅ is C₁-C₆-alkyl possibly substituted with heterocycle, or R₃ and R₅ form together divalent C₈-C₁₄-radical. Indicated compounds are synthesized by interaction of compound HCOO-CH(OH)--CHR₂--C(O)-NH--CR₃H--C(O)-N-R₄R₅ with hydroxylamine. Compounds of the formula (I) show inhibition effect with respect to metalloproteinase activity and tumor necrosis factor formation and can be used in the corresponding pharmaceutical composition. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 21 cl, 10 ex