N-SUBSTITUTED 3-AZABICYCLO[32,0]HEPTANE DERIVATIVES Russian patent published in 1999 - IPC

FIELD: biologically-active compounds. SUBSTANCE: new N- substituted 3-azabicyclo[32.0] heptane derivatives with formula I (presented in description) are provided, where R¹ is phenyl or thienyl optionally monosubstituted by nitro, amino, mono- or dimethylamino group; A is group of formula II wherein R² is hydrogen, R³ hydrogen or R² and R³ together form oxygen atom; R⁴ optionally fluoro- or chloro-substituted thienyl or naphthyl; R⁵ hydrogen or methyl; R⁶ phenyl disubstituted by fluorine or fluorine, monosubstituted by amino, C₁-C₄-alkylamino, or di-C₁-C₄-dialkylamino, or thienyl, naphthyl, benzofuryl, benzothienyl, indolyl, N-methylindolyl, N-methylindenyl, or C₃-C₆- cycloalkyl each optionally substituted by fluorine or chlorine atoms; R⁷ hydrogen, fluorine, chlorine, C₁-C₄-alkyl, or amino group; R⁸ hydrogen or methyl; R⁹ hydrogen or methyl, or R⁸ and R⁹ together with annular carbon atom form spiro-cyclopropane ring; R¹⁰ phenyl, benzyl, or cyano group; and n=1,2,3 or 4; and their salts with physiologically tolerable acids. Compounds I function as D₄ dopamine receptor antagonists and can be utilized as neuroleptics and brain-protection drugs. EFFECT: extended choice of neuroleptics. 2 cl, 56 ex