DERIVATIVES OF N-SUBSTITUTED 3-AZABICYCLO-[3,2,0]-HEPTANE AND THEIR SALTS WITH PHYSIOLOGICALLY ACCEPTABLE ACIDS AND PHARMACEUTICAL COMPOSITION WITH ANTIPSYCHOTIC ACTIVITY Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes novel derivatives of N-substituted 3-azabicyclo-[3.2.0]-heptane of the formula (I) where R¹ is naphthyl or phenanthryl group that can be substituted with halogen atoms; n = 1-4; R² is C_1-4-alkyl group or in common with adjacent carbon atom it means carbonyl group; X and Y are carbon atoms, N-alkyl C_1-4-groups, -NH- or nitrogen atoms; Z means direct bond, carbonyl or CH-group; A is C_1-4-alkylamino-group or in common with Y it is a part of condensed thiazole, pyridine or benzene ring that can be substituted with chlorine or fluorine atoms and their salts with physiologically acceptable acids. These compounds show antipsychotic activity. Invention relates to pharmaceutical compositions based on these compounds also. EFFECT: new compounds indicated above, valuable medicinal properties. 3 cl, 1 tbl, 10 ex