DERIVATIVES OF 1,2,4-TRIAZOLO[1,5-A]PYRIMIDINES, THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND STEREOISOMERS, PHARMACEUTICAL COMPOSITION AND METHOD OF ATTACK SUPPRESSION Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to new nitrogen-containing heterocyclic compounds showing biological activity, mainly to derivatives of 1,2,4-triazolo[1,5-a]pyrimidines, their pharmaceutically acceptable salts and stereoisomers, a pharmaceutical composition containing their and a method of suppression of attacks. Invention describes derivatives of 1,2,4-triazolo[1,5-a] - -pyrimidines of the general formula (I) where R₁, R₄, R₅ - hydrogen atom; or alkyl with 1-6 carbon atom; R₂, R₃ - hydrogen atom; R₆, R₇, R₈ mean independently each of other hydrogen, halogen atom, cyano-group, alkanoyl with 1-6 carbon atoms, alkoxyl with 1-6 carbon atoms that can be free or substituted with halogen atom, alkylthio-group with 1-6 carbon atoms, alkylsulfonyl with 1-6 carbon atoms, alkylsulfinyl with 1-6 carbon atoms, alkyl with 1-6 carbon atoms that can be free or substituted with halogen atom. If R₁, R₂, R₃, R₄, R₈ - hydrogen atoms, R₅ - methyl, R₆, R₇ - hydrogen atoms or R₈ is 4-chloro- and R₇ - hydrogen atom or 2-chloro- then the compound of the formula (I) is not racemate and their pharmaceutically acceptable salts and stereoisomers. Invention describes the pharmaceutical composition showing an anticonvulsant activity on the base of compounds of the formula (I) and a method of suppression of attacks using compounds of the formula (I). EFFECT: valuable pharmacological properties of compounds. 11 cl, 31 ex