PHARMACEUTICAL COMPOSITION Russian patent published in 1999 - IPC

FIELD: medicine, pharmacy. SUBSTANCE: invention claims a tablet for a single oral administration of drug in colon intestine. Tablet has an internal core at amount 10-45% of tablet mass, surrounding labile polymeric layer and an enterosoluble envelope that surrounds its. Internal core has the biologically active compound and a pharmaceutically acceptable carrier. Labile polymeric layer has 30-85% of tablet mass and its thickness is 2-3.5 mm. It is made of the pharmaceutically acceptable derivative of cellulose ester and viscosity of its 2 wt.-% solution is 3-100 sP. Enterosoluble envelope has 5-25% of tablet mass and its thickness is about 50-300 mcm. Labile polymeric layer can include microcrystalline cellulose additionally at mass ratio of derivative of cellulose ester to microcrystalline cellulose from 6:1 to 0.5:1. The preferable derivative of cellulose ester is hydroxypropylcellulose, hydroxypropylmethylcellulose or their mixture. Invention ensures to deliver drugs in colon intestine without use of enema medicinal forms. EFFECT: enhanced effectiveness of the composition. 5 cl, 3 dwg, 2 ex