FIELD: pharmacy. SUBSTANCE: invention relates to new polypeptides showing an antithrombin activity. Polypeptides are produced from tissues or secrets of leeches of order Rhynchobdellida, mainly of species Theromyzon tessulatum. Molecular mass of polypeptides is about 14 kDa, 9 kDa and they can be used in pharmaceutical compositions for treatment of disorders and states induced by thrombosis. EFFECT: broadened arsenal of thrombin inhibitors. 10 cl, 10 dwg, 2 tbl, 11 ex
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