CYCLIC AZAPEPTIDES WITH ANGIOGENIC EFFECT Russian patent published in 2002 - IPC

FIELD: organic chemistry, peptides. SUBSTANCE: invention describes novel cyclic azapeptides of the general formula (I): cyclo-(aArg-aGly-aAsp-aX-aY) where aArg means Arg; aGly means azaGly; aAsp means Asp; aX means amino acid residue taken among the group including Lys and Phe; aY means amino acid residue taken among the group Val, Gly, Ala, Leu; in the case of optically active amino acid residues and amino acid derivatives then this term involves both L- and D-forms and also salts of indicated compounds. Invention relates to a method of synthesis of end compounds of the formula (I) by cyclization of the corresponding linear peptide and the following conversion of synthesized product to one of its salts and a pharmaceutical composition showing ability to inhibit the interaction of integrin receptors with ligands and comprising at least one compound of the formula (I) as an active component. The described compounds show a higher ability to inhibit the interaction of integrin receptors with ligands as compared with corresponding compounds no containing azaleino acids. EFFECT: valuable pharmacological properties. 5 cl, 1 tbl, 1 ex