DIHYDROBENZOFURANS, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION ON SAID Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes new dihydrobenzofurans of the general formula (I) where R₁ means C₁-C₆-alkoxyl or C₁-C₄-alkoxyl partially or completely substituted with fluorine atoms; R₂ means C₁-C₄-alkyl and R₃ means hydrogen atom or C₁-C₄- -alkyl; or R₂ and R₃ in common including both carbon atoms to which they bound form 5-, 6- or 7-membered carbon ring optionally broken by oxygen atom; R₄ means phenyl, pyridyl substituted with radicals R41, R42, and R43, phenyl or pyridyl substituted with radicals R44, R45, R46 and R47 where R41 means halogen atom or C₁-C₄-alkyl; R42 means hydrogen, halogen atom or C₁-C₄-alkyl; R43 means hydrogen, halogen atom or C₁-C₄-alkyl; R44 means halogen atom or C₁-C₄-alkyl; R45 means hydrogen or halogen atom; R46 means hydrogen or halogen atom; R47 means hydrogen or halogen atom and their salts. Compounds are new effective inhibitors of phosphodiesterase and can be used for treatment of patients with respiratory way diseases and dermatosis. Invention describes a method of their synthesis and a pharmaceutical composition on their base. EFFECT: improved method of synthesis, valuable pharmacological properties. 10 cl, 2 dwg, 9 tbl, 14 ex