FIELD: chemistry of peptides. SUBSTANCE: invention describes polypeptides of the formula (I): 0 1 2 3 4 5 6 7 8 9 10 11 12 (A)-Gly-Ile-Pro-B-B-Pro-Val-His-Leu-Lys-Arg-Leu- 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 -Leu-Ile-Val-Val-Val-Val-Val-Val-Leu-Ile-Val-Val-Val-Ile-Val- 28 29 30 31 32 33 34 -Gly-Ala-Leu-Leu-C-Gly-Leu where A means H or Phe, B means Phe or Trp and C means Ile, Leu or Ser that show activity of pulmonary surface-active substance. These polypeptides are synthesized with high yield and high purity degree and their effectiveness is comparable with that to natural pulmonary surface-active substances. They can be used for preparing pharmaceutical compositions used for treatment of newborns and adults with dyspnea syndrome. EFFECT: enhanced effectiveness of polypeptides. 9 cl, 4 ex
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