ENALAPRIL MALEATE-BASE SOLID MEDICINAL FORM Russian patent published in 1999 - IPC

Abstract RU 2140261 C1

FIELD: medicine, pharmacy. SUBSTANCE: enalapril maleate-base solid medicinal form is made as pressed granules (size is 0.75 mm) powdered with a mixture of starch and magnesium or calcium stearate. Granules have a mixture of enalapril maleate on matrix made of polyvinylpyrrolidone with starch and lactose. The form has enalapril maleate at the therapeutically effective amount, lactose 48-52 mas. p.; starch 33-42 mas. p.; polyvinyl-pyrrolidone 1-2 mas. p.; calcium or magnesium stearate 1 mas. p. being 17-60% of starch mass can be as component of granules and 40-83% - as component of powdering mixture. The preferable content of enalapril maleate - 10 mg. The form exhibits good decomposition after its intake by patient and does not enter harmful and inert substances in the body as a result of balanced composition of components. The proposed medicinal form can be used for treatment of patients with arterial hypertension and cardiac failure. EFFECT: enhanced effectiveness of the form, improved quality and properties. 3 cl, 4 ex

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RU 2 140 261 C1

Authors

Prokhoda E.F.(Ru)

Bulatov A.E.(Ru)

Shtejngart Mark Vol'Fovich

Skakun Nona Nikolaevna

Goncharov Nikolaj Ivanovich

Dikhtjarev Sergej Ivanovich

Chajka Leonid Aleksandrovich

Dates

1999-10-27Published

1997-04-03Filed