FIELD: pharmaceutics. SUBSTANCE: pharmaceutical composition is designed in the form of membrane-covered center. The latter contains efficient quantity of indapamide as active substance. As pharmaceutically acceptable target additives the center contains, weight portion/1 weight portion indapamide: polyvinylpyrrolidone at average mol. wt. being above 19000, 0.3-2.4; saccharide, 15.0-33.0; starch, 4.2- 12.0; sodiumdodecylsulfate, 0.001-0.5; stearic acid and/or its salt and/or talc, 0.1-2.1. Preferably, the center includes pressed powdered granules. Method to obtain pharmaceutical composition includes wet granulating the mixture of indapamide with saccharide, starch, polyvinylpyrrolidone, sodiumdodecylsulfate and, not obligatory, talc, followed by drying, addition of powdering agent, formation of the mixture into the center and application of membrane onto centers obtained. Said composition has got resistance at keeping and storage terms above 2 years, is easily decomposed that provides high degree of indapamide releasing. Sequence in operations conducted and technological parameters of the present method provide manufacturing medicinal form of satisfactory strength. EFFECT: improved results. 14 cl, 4 ex
