TRIPLATINUM (II) COMPLEXES, AND METHOD OF PREPARING THEREOF Russian patent published in 1999 - IPC

Abstract RU 2140422 C1

FIELD: chemical industry. SUBSTANCE: described are triplatinum (II) complexes of general formula I: wherein X, Y, Z and T are neutral and/or ligands which are the same or different provided that at least one of X, Y or Z at each Pt (b) must be anionic ligand; A is bridge diamine agent NH2-(CH2)s-NH2-, n is fuel charge of coordination triplatinum spheres; P is one or more counterions which are present or are not present depending on the fact whether coordination triplatinum spheres have common charge, m is number of counterions and is equal to integer of 0 to 2 inclusive. Also described is method of preparing triplatinum complexes. Due to the presence of there coordination triplatinum spheres in the claimed triplatinum complexes, the latter allow for intensified cytotoxic activity as compared with mono- and bis-platinum complexes employed at present. EFFECT: improved properties of the title compounds and more efficient preparation method. 12 cl, 2 ex, 2 tbl

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RU 2 140 422 C1

Authors

Nikolas Farrell

Jun K'Ju

Dzhejms D.Kheshel'

Dates

1999-10-27Published

1994-05-25Filed