TRIPLATINUM (II) COMPLEXES, AND METHOD OF PREPARING THEREOF Russian patent published in 1999 - IPC

Abstract RU 2140422 C1

FIELD: chemical industry. SUBSTANCE: described are triplatinum (II) complexes of general formula I: wherein X, Y, Z and T are neutral and/or ligands which are the same or different provided that at least one of X, Y or Z at each Pt (b) must be anionic ligand; A is bridge diamine agent NH2-(CH2)s-NH2-, n is fuel charge of coordination triplatinum spheres; P is one or more counterions which are present or are not present depending on the fact whether coordination triplatinum spheres have common charge, m is number of counterions and is equal to integer of 0 to 2 inclusive. Also described is method of preparing triplatinum complexes. Due to the presence of there coordination triplatinum spheres in the claimed triplatinum complexes, the latter allow for intensified cytotoxic activity as compared with mono- and bis-platinum complexes employed at present. EFFECT: improved properties of the title compounds and more efficient preparation method. 12 cl, 2 ex, 2 tbl

Similar patents RU2140422C1

Title Year Author Number
TRINUCLEAR CATIONIC PLATINUM COMPLEXES HAVING ANTITUMOR ACTIVITY, METHOD OF PREPARING THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPLEXES 1995
  • Mariella Valsekki
  • Marko Konti
  • Luiza Del' Greko
  • Karlo Bugatti
  • Ehrnesto Menta
  • Ferdinando Gil'Jani
  • Karla Mantsotti
  • Sil'Vano Spinelli
  • Nikolas Farrell
RU2130941C1
CISPLATINUM COMPLEX AND METHOD FOR ITS PREPARING 2000
  • Vong Ehrnest S. J.
  • Dzhandomeniko Kristen M.
RU2245340C2
(2,4- DIOXO -1,3-BIS - (5- METHYL -3- THIAHEXYL)-6-METHYL- 1,2,3,4- TETRAHYDROPYRIMIDINE -S,S) -CIS - DICHLOROPLATINUM SHOWING IMMUNOTROPIC ACTIVITY 1991
  • Tolstikov G.A.
  • Murinov Ju.I.
  • Krivonogov V.P.
  • Afzaletdinova N.G.
  • Khisamutdinov R.A.
  • Zarudij F.S.
  • Lazareva D.N.
  • Ismagilova A.F.
  • Volkova S.S.
RU2028300C1
BIS- [2,4- DIOXO-6- METHYL -1,2,3,4- TETRAHYDROPYRIMIDINE -3- (5-MET- HYL-3-THIAHEXYL) -S] -CIS- DICHLOROPLATINUM SHOWING IMMUNOTROPIC ACTIVITY 1991
  • Tolstikov G.A.
  • Murinov Ju.I.
  • Krivonogov V.P.
  • Afzaletdinova N.G.
  • Khisamutdinov R.A.
  • Zarudij F.S.
  • Lazareva D.N.
  • Ismagilova A.F.
  • Volkova S.S.
RU2035467C1
METHOD OF OBTAINING CIS-DIAMMINO(1,1-CYCLOBUTANEDICARBOXYLATE)PLATINUM(II) 2006
  • Ivanova Lidija Vladimirovna
  • Vostrikov Vladimir Aleksandrovich
  • Mamonov Sergej Nikolaevich
RU2330039C1
PLATINUM (IV) COMPLEXES WITH HIGH ANTITUMOR EFFICIENCY 2014
  • Kisilka Vladimir
  • Mengler Yan
  • Gavlovits Karel
  • Katser Petr
  • Tserveny Libor
RU2666898C1
MESOSCOPIC ORGANOPOLYSILOXANE PARTICLES WITH CHEMICALLY BOUND METAL COMPOUNDS 1996
  • Baumann Frank
  • Dojbtser Bernvard
  • Gek Mikhel'
  • Shmidt Manfred
RU2149879C1
METHOD OF OBTAINING CIS-DICHLORODIAMMINEPLATINUM (II) 2013
  • Goncharova Ekaterina Sergeevna
  • Shipachev Vladimir Alekseevich
  • Levchenko Ljudmila Mikhajlovna
RU2538895C2
BLEACHING COMPOSITION AND METHOD FOR BLEACHING SUBSTRATE 1999
  • Appel Adrianus Kornelis Marija
  • Karina Rikkardo Filippo
  • Del'Ruass Mishel' Zhil'Ber Zhoz
  • Feringa Bernar Ljuka
  • Zhirer Zhan-Zhak
  • Khage Ronal'D
  • Kalmejer Robertus Ehverardus
  • Martens Konstantinus Fransiskus
  • Pelen Jakobus Karolina Jokhannes
  • Kve Lorens
  • Svartkhof Ton
  • Tetard Dehvid
  • Torntvejt Dehvid
  • Tivari Laksmikant
  • Tejssen Rob
  • Tvisker Robin Stefan
  • Verman Simon Marinus
  • Van Der Vut Gerrit
RU2235125C2
METHOD FOR PROCESSING OF TEXTILE ARTICLES 1999
  • Appel Adrianus Kornelis Marija
  • Karina Rikkardo Filippo
  • Del'Ruass Mishel' Zhil'Ber Zhoz
  • Feringa Bernar Ljuka
  • Zhirer Zhan-Zhak
  • Khage Ronal'D
  • Kalmejer Robertus Ehverardus
  • Martens Konstantinus Fransiskus
  • Pelen Jakobus Karolina Jokhannes
  • Kve Lorens
  • Svartkhoff Ton
  • Tetard Dehvid
  • Torntvejt Dehvid
  • Tivari Laksmikant
  • Tejssen Rob
  • Tvisker Robin Stefan
  • Verman Simon Marinus
  • Van Der Vut Gerrit
  • Smit Richard Dzhordzh
RU2240391C2

RU 2 140 422 C1

Authors

Nikolas Farrell

Jun K'Ju

Dzhejms D.Kheshel'

Dates

1999-10-27Published

1994-05-25Filed