CISPLATINUM COMPLEX AND METHOD FOR ITS PREPARING Russian patent published in 2005 - IPC

FIELD: metalloorganic chemistry, chemical technology.

SUBSTANCE: invention relates to the improved method for preparing platinum complexes having the formula (Ia) or (Ib) given in the description. Method involves: 1a) the first stage wherein [PtA₄]^2- interacts with L under corresponding conditions in the first solvent to yield [PtA₃(L)]^-; 1b) the second stage wherein [PtA₃(L)]^- interacts with L' under corresponding conditions in the second solvent to yield cis-[PtA₂(L')(L)]; 1c) in the case when Y represents halogen atom or hydroxy-group the third stage wherein cis-[PtA₂(L')(L)] interacts with H₂O₂, Y₂ or halogen containing oxidant to yield c,t,c-[PtA₂Y₂(L')(L)]; in the case when Y represents ester of carboxylate, carbamate or carbonate the forth stage wherein intermediate compound and wherein Y represents hydroxy-group obtained at the stage 1c) is functionalized with corresponding acylating agent; and 1d) in the case when A doesn't represent halide or differs from the parent halide the additional stage (stages) wherein at the first stage halide A of intermediate compound obtained at stage 1a), 1b), 1c) or 1d) is converted to another halide and new removing group (groups) A, such as monodentate hydroxy-, alkoxy-, carboxylate or bidentate carboxylate, phosphonocarboxylate, diphosphonate or sulfate wherein L, L' and Y have values in the description.

EFFECT: improved preparing method, expanded assortment of platinum-containing medicinal agents.

33 cl, 3 tbl, 9 dwg, 23 ex