AVIRULENT STRAIN VIBRIO CHOLERAE OF NON 01-SEROGROUP (VARIANTS), METHOD OF STRAIN PREPARING (VARIANTS), VACCINE Russian patent published in 1999 - IPC

Abstract RU 2140981 C1

FIELD: microbiology. SUBSTANCE: invention relates to avirulent strains of Vibrio Cholerae (CVD 112 and CVD 12RM) of non 01-serogroup that have no the RS1-sequence and core sequence of choleraic enterotoxin. Strains have sequences encoding the resistance to mercury and sequences encoding B-subunit of choleraic enterotoxin repeatedly inserted into chromosome. Invention relates to also methods of preparing avirulent strains of Vibrio Cholerae (CVD 112 and CVD 112RM) of non 01-serogroup. Avirulent strains Vibrio Cholerae CVD 112 and CVD 112RM of non 01-serogroup are used for production of vaccine against cholera. EFFECT: improved method of preparing the strain and vaccine. 16 cl, 40 dwg, 14 ex

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RU 2 140 981 C1

Authors

Kaper Dzhejms

Levin Majron

Dates

1999-11-10—Published

1994-10-07—Filed