METHOD OF CLODRONATE PREPARATION PREPARING Russian patent published in 1999 - IPC

FIELD: pharmacy. SUBSTANCE: clodronate is crystallized as clodronate disodium tetrahydrate from clodronate disodium an aqueous solution. Formed clodronate disodium tetrahydrate is subjected for dry granulation by compression being crystalline lattice of clodronate disodium tetrahydrate remains to be intact. Then method involves stages of grinding and screening through a sieve and granules of definite size are isolated. If necessary the dried granulated clodronate disodium tetrahydrate is mixed with filling, lubricating and disintegrating agents. Crystallization is performed by addition of partially or completely water-soluble an organic solvent to clodronate disodium tetrahydrate solution where clodronate disodium is difficultly soluble followed by graduate decrease of initial temperature that is above the room one. The stage of wet granulation is excluded in the process. EFFECT: simplified method of preparing, high quality of granules, stable properties of the preparation. 18 cl, 6 ex