FIELD: organophosphorus compounds. SUBSTANCE: products: derivatives of methylene-bis-phosphonic acid of the formula (I) 
where: R1,R2,R3 and R4 - independently C1-C22-alkyl or hydrogen; Q1 and Q2 - chlorine at condition that of groups R1-R4 - hydrogen and at least one of groups R1-R4 is distinct from hydrogen including their stereoisomers and pharmaceutically acceptable salts. Reagent 1: methylene-bis-phosphonic acid tetraester. Reagent 2: water. Reaction conditions: in the presence of inorganic or organic acid or base, at 20-150 C. Synthesized compounds were used in medicine for metabolism regulation. EFFECT: improved method of synthesis. 7 cl, 1 tbl
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