FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes new derivatives of oxazoloquinolinone of the general formula (I) 
where values R1-R5 are given in p. 1 of the invention claim. Compounds show the selective inhibitory activity with respect to MAO-A or inhibitory activity with respect to both MAO-A and MAO-B. Invention describes also a method of their synthesis and drugs that can be used for treatment of patients with depressive states, panic attacks, phobia, fear, migraine, age mental disorders or dementia and for prophylaxis or treatment of neurodegenerative diseases. EFFECT: improved method of synthesis, enhanced curative effectiveness. 12 cl, 3 dwg, 1 tbl, 15 ex
| Title |
Year |
Author |
Number |
| METHOD OF PRODUCING HETEROCYCLIC COMPOUNDS WITH CONDENSED BENZENE |
0 |
- Ikuo Ueda
- Euiti Siokava
- Takasi Manabe
- Esuke Katsura
|
SU1375137A3 |
| TRICYCLIC NITROGEN-CONTAINING COMPOUNDS AND TETRAHYDROQUINOLINE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS |
1991 |
- Mal'Kol'M Vilson Mun[Us]
- Richard Frederik Khejer[Us]
- Dzhenett Kej Morris[Us]
|
RU2023712C1 |
| DERIVATIVES OF 5-(HYDROXYMETHYL)-OXAZOLIDINE-2-ONE, METHODS OF THEIR SYNTHESIS, REMEDY AND PHARMACEUTICAL COMPOSITION |
1996 |
- Jegam Samir
- Pjueh Frederik
- Bjurn'E Filip
|
RU2164226C2 |
| BENZOPYRANS, METHOD OF PREPARATION THEREOF, INTERMEDIATE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS |
1996 |
|
RU2160735C2 |
| DERIVATIVES OF 3-(2-AMINOETHYL)-4-[3-(TRIFLUOROMETHYL)BENZOYL]- -3,4-DIHYDRO-2H-1,4-BENZOXAZINE, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION CONTAINING ON SAID |
1995 |
- Zhorzh Paskal'
- Frost Dzhonatan
- Paso Patrik
- Russel' Korinn
- Barch Rezhin
- Vil'Jams Pol Khauard
- Mjuller Zhan-Klod
|
RU2136670C1 |
| DERIVATIVES OF BENZOXAZINE, METHODS OF THEIR SYNTHESIS, A PHARMACEUTICAL PREPARATION |
1994 |
- Pol Khovard Uil'Jamz
- Lidija Zard
- Tomas Ehndrju Parsell'
- Daniel' Gal'T'E
- Zhan-Klod Mjuller
- Paskal' Zhorzh
- Dzhonatan Frost
- Patrik Pazo
- Korin Russel'
- Rezhin Bartsh
|
RU2130020C1 |
| CRYSTALLINE FORM OF COMPOUND USED AS A MINERALOCORTICOID RECEPTOR ANTAGONIST AND THE METHOD OF ITS PRODUCTION |
2013 |
- Tszyan Chen
- Van Ajchen
- Chzhan Dedun
|
RU2622105C2 |
| BENZYLPIPERIDINE DERIVATIVES, METHOD OF PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION AND METHOD OF PREPARATION THEREOF |
1995 |
- Khel'Mut Prjukher
- Rudol'F Gottshlikh
- Joakhim Lajbrok
- Kharri Shvartts
|
RU2160259C2 |
| N-[3-(5-AMINO-3,3A,7,7A-TETRAHYDRO-1H-2,4-DIOXA-6-AZA-INDEN-7-YL)-PHENYL]-AMIDES AS INHIBITORS OF BACE1 AND(OR) BACE2 |
2012 |
- Khilpert Khans
- Khumm Roland
|
RU2597308C2 |
| DERIVATIVES OF N-(3-AMINOPROPYL)-N-PHENYL-5,6,7,8-TETRAHYDRO- -NAPHTHALENE-2-CARBOXAMIDE, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION |
1995 |
- Zhorzh Paskal'
- Frost Dzhonatan
- Paso Patrik
- Russel' Korinn
- Barch Rezhin
- Vil'Jams Pol Khauard
- Mjuller Zhan-Klod
|
RU2138479C1 |
