DERIVATIVES OF 3-(2-AMINOETHYL)-4-[3-(TRIFLUOROMETHYL)BENZOYL]- -3,4-DIHYDRO-2H-1,4-BENZOXAZINE, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION CONTAINING ON SAID Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes new derivatives of 3-(2-aminoethyl)-4-[3-(trifluoromethyl)benzoyl] - -3,4-dihydro-2H-1,4-benzoxazine in the form of pure optical isomers or their mixture and corresponding to the general formula (I) where R₁ means hydrogen, fluorine or chlorine atom or methyl, C₁-C₃-alkoxy- or nitro-group; R₃ means separately hydrogen atom or C₁-C₃-alkyl group; R₄ corresponds separately to 2,3-dihydro-1H-indene-2-yl group, 2,3-dihydro-1H-indene-1-yl group or 1,2,3,4-tetrahydronaphthalene-1-yl group or in an alternative case R₃ and R₄ in common with nitrogen atom to which they bound form 1,2,3,4-tetrahydro-9H-pyrido[3,4-b] -indole-2-yl group, 1,2,3,4-tetrahydro-9H-pyrido[4,3-b] indole-3-yl group, 4,5,6,7-tetrahydrothieno[2,3-c] pyrido-6-yl group, 4,5,6,7-tetrahydrothieno[3,2-c] pyrido-6-yl group or 2,3-dihydro-1H-isoindole-2-yl group of formulas (a,b,c,d,e) as bases or salts obtained by acids addition. Compounds of the formula (I) can be used as therapeutic agents. Invention describes also a method of synthesis the above indicated compounds and the pharmaceutical composition containing their that can be used for treatment of patients with pathology associated with dysfunction of neurone calcium homeostasis. EFFECT: improved method of synthesis, valuable pharmacological properties. 4 cl, 2 tbl, 7 ex