DERIVATIVES OF N-(3-AMINOPROPYL)-N-PHENYL-5,6,7,8-TETRAHYDRO- -NAPHTHALENE-2-CARBOXAMIDE, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of N-(3-amino- -propyl)-N-phenyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide of the formula (I) where R₁ - hydrogen, halogen atom, methyl or alkoxy-group; - hydrogen, halogen atom; - H or methoxy-group; R₃ is C_1-3-alkyl; R₄ is 2,3-dihydro-1H- -indene-2-yl, 2,3-dihydro-1H-indene-1-yl, 1,2,3,4-tetrahydro- -naphthalene-1-yl or R₃,R₄ in common with nitrogen atom form 1,2,3,4-tetrahydroisoquinolyl, 6,7-dimethoxy-1,2,3,4-tetra- -hydroisoquinolyl (other values see in p. 1 of the invention claim) as a base or salt, the pure isomer or a mixture of isomers which show an anti-ischemic activity. EFFECT: improved method of synthesis, valuable pharmacological properties. 7 cl, 1 tbl, 52 ex