FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to sulfamide compounds of the general formula (I) 
where R - naphthyl or biphenyl possibly substituted R1, R2; R1, R2 - C1-4-alkyl or -NR7R8; R4, R5 - H or C1-4-alkyl; R7, R8 is C1-4-alkyl; R12 - halogen atom, or their pharmaceutically acceptable salts that are antagonists of endothelin receptors and can be used as hypotensive agents. EFFECT: valuable hypotensive properties of compounds. 14 cl, 5 ex
