SUBSTITUTED BIPHENYLSULFONAMIDES, PHARMACEUTICAL COMPOSITION BASED ON THESE COMPOUNDS, AND METHOD FOR ANTAGONISTIC ACTION OF ENDOTHELIN Russian patent published in 2000 - IPC

FIELD: pharmaceutical chemistry. SUBSTANCE: invention provides novel biphenylsulfonamides with general formula I: (I), in which one of X and Y is oxygen and the other nitrogen; each of R¹ and R² is directly linked to endocyclic carbon atom and each independently from the other denotes hydrogen or lower alkoxy group; each of R³ and R⁴ is directly linked to endocyclic carbon atom and each independently from the other denotes lower alkyl; each of R¹²,R¹³ and R¹⁴ denotes hydrogen atom; R¹¹ is hydrogen or lower alkyl optionally substituted with Z¹,Z²,Z³, of which each independently can be hydrogen atom or Z¹ is group Z⁴-NZ⁷Z⁸ or Z⁴-N(Z¹¹)Z⁵-Z⁶, wherein Z⁴ is ordinary bond, Z⁵ ordinary bond or C= O group, Z⁶ lower alkyl optionally substituted by 3 halogen atoms or cycloalkylalkyl, Z⁷ hydrogen, and Z⁸ lower alkyl, or yet Z¹ can be 2-oxopyrrolydinyl or substituted pyrazolyl; J, K, L, T, and U, independently from each other, are nitrogen or carbon atoms on condition that at least one of them is nitrogen and no more than two of them are nitrogens and also, when only one of J, K, L, T, and U is nitrogen, the latter can be oxidized into N-oxide; and p=0. EFFECT: increased choice of endothelin-active therapeutic agents. 9 cl, 18 ex