PIPERAZINYL- AND PIPERIDINYLCYCLOHEXANOLES AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, PHARMACEUTICAL COMPOSITION AND A METHOD OF SEROTONINERGIC NEUROTRANSMISSION INCREASE Russian patent published in 1997 - IPC

FIELD: organic chemistry. SUBSTANCE: product: piperazinyl- and piperidinylcyclohexanols of the general formula (I) and their pharmaceutically acceptable salts where: R₁ and R₂ - H, halogen, CF₃, C₁ - C₄-alkoxy being R₁ and R₂ can not mean H simultaneously; R₁ and R₂ can form together bridge -O-(CH₂)_n-O- where n = 1-3 if they are near vicinity carbon atoms; R₃ - H, C₁ - C₄-alkyl; R₄ and R₅ - H, C₁ - C₄-allyl or phenyl; Y - N or CH; Ar - phenyl, 2-thienyl or substituted phenyl of the formula -(C₆H₄)X_pX1q

where: substituents X and X¹ - halogen, nitro, C₁ - C₄-alkyl, C₁ - C₄-alkoxy and X and X¹ together form bridge -O-(CH₂)_n-O- where n = 1-3; p and q - whole numbers 0-5 being p + q ≅ 5. Pharmaceutical composition has substance of the formula (I) and can bind serotoninergic 5-HT_IA receptor. Method of treatment of serotoninergic neurotransmission involves administration of compound of the formula (I). EFFECT: improved method of synthesis, enhanced effectiveness of treatment. 17 cl