BIPHENYLISOXAZOLSULFONAMIDES Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacology. SUBSTANCE: invention describes novel compounds of the formula (I) or their pharmaceutically acceptable salts where X is O; Y is N; 7 is O, S, N-R¹⁵, k and z-c or N under condition that one of their is C; p = 0, 1; R' is hydrogen atom, lower alkyl, the group Z⁴-NR⁶R⁷ where Z⁴ means the group Z⁹COZ¹⁰ and each of Z⁴,Z⁹,Z¹⁰ means a single bond; R⁶ is hydrogen atom, alkyl; R⁷ is hydrogen atom; R² is hydrogen atom or lower alkyl; R³ and R⁴ each is lower alkyl; each of R¹²,R¹³,R¹⁴ is hydrogen atom; R¹⁵ is hydrogen atom, alkyl, hydroxyethoxymethyl, methoxyethoxymethyl; R¹¹ is hydrogen atom, hydroxyl, CO₂R⁵ where R⁵ is alkyl, oxazolyl, alkenyl substituted with phenyl; Z⁴ is NR⁶R⁷ where Z⁴ means Z⁹COZ¹⁰ where Z⁹ and Z¹⁰ each means a single bond; R⁶ and R⁷ are given above; alkyl substituted with the group Z² where Z² is hydroxyl, the group where Z⁴ is a bond; Z⁵ is groups Z⁹COZ¹⁰,Z⁹COOZ¹⁰,Z⁹S(O)_nZ¹⁰; Z⁹,Z¹⁰ each a single bond; Z¹¹ is hydrogen, alkyl; Z⁶ is hydrogen, alkyl, phenyl, phenyl substituted with one halogen atom, alkyl substituted with three halogen atoms; n = 2, or Z² means the group where Z⁴ is a single bond; Z⁵ is the group Z⁹COZ¹⁰ where Z⁹ and Z¹⁰ mean a single bond; Z⁹ is hydrogen atom; Z⁸ is alkyl, phenyl; Z¹¹ is hydrogen, alkyl. Compounds are antagonists of endothelin. EFFECT: new compounds indicated above, valuable pharmacological properties. 15 cl, 1 tbl, 43 ex